The Worry About Clopidogrel “Nonresponsiveness”

Genetic causes of clopidogrel nonresponsiveness: which ones really count?

Clopidogrel decreases the morbidity and mortality associated with several cardiovascular diseases. However, clopidogrel is a prodrug that needs to be metabolized to the active thiol metabolite by the cytochrome P450 (CYP) system. This activation is a source of significant interindividual variability in clopidogrel responsiveness. Drug interactions with and genetic variation in CYP3A4, CYP3A5, a...

Should Judges Worry About the “CSI Effect”?

Population ageing: what should we worry about?

Approximately half the world's population now has replacement-level fertility or below. The UK experience in accommodating to a changing dependency ratio provides some generalizable insights. A mechanistic approach assuming a fixed retirement age and a need to raise fertility or increase immigration in order to maintain pensions at a fixed proportion of the gross domestic product (GDP) is overs...

Should Designers Worry about Market Systems ?

Engineering approaches for optimizing designs within a market context generally take the perspective of a single producer, asking what design and price point will maximize producer profit predicted by consumer choice simulations. These approaches treat competitors and retailers as fixed or nonexistent, and they take business-oriented details, such as the structure of distribution channels, as s...

CNS mastitis: nothing to worry about?

In this paper, we analyzed a very large field data set on intramammary infections (IMI) and the associated somatic cell count (SCC) in dairy cows. The objective of the study was to analyze the impact of coagulase-negative staphylococci (CNS) IMI on cow SCC, both mean and variability, and on the potential of these infections to have a major impact on the bulk milk SCC (BMSCC). Data and milk samp...